Approach to the enantioselective synthesis of achillifoline
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Abstract
In this paper, an approximation biomimetic synthesis of achillifoline, a natural sesquiterpene lactone isolated from Achillea millefolium subsp. Millenium, is presented. Carbocationic cyclization of epoxy-costunolide is the key step of the synthetic sequence. This transannular cyclization, allows the formation of the skeleton of 1,4-epoxy-cyclodecane presents in achillifoline
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Approach to the enantioselective synthesis of achillifoline. REMCB [Internet]. 2017 Aug. 15 [cited 2026 Oct. 25];35(1-2):41-50. Available from: https://remcb-puce.edu.ec/remcb/article/view/257