Rosai Dorfman's Disease and Reactivation of Toxoplasmosis: Case Report
Article Sidebar
Main Article Content
Abstract
Rosai Dorfman's disease is an extremely rare clinical entity characterized by a disseminated
histiocytic proliferation. It usually affects young adults, presenting with multiple lymphadenopathy, which
constitutes a differential diagnosis of several infectious and lymphoproliferative entities. Next, we present
a case of this disease and a review on the subject.
Description of the case
A 32-year-old male patient presented recurrent generalized lymphadenopathy accompanied by fever,
episodic skin rash and malaise. At examination he had several adenopathies located on the supraclavicular and axillary region. Laboratory studies were conducted which were not relevant except for exaggerated
levels of IgG against toxoplasma. In tomography disseminated lymph node proliferation was found at the
cervical, thoracic, axillary and abdominal levels. A biopsy of the right supraclavicular ganglion showed the
presence of a histiocytic infiltrate with positive immunohistochemistry for S100, a finding compatible with
Rosai Dorfman's disease.
Conclusions
Rosai Dorfman disease is an often ignored entity which constitutes an interesting differential diagnosis in
young patients with generalized adenomegalies, so its presence should always be suspected in any atypical
or recurrent cases such as the one presented in this review.
Downloads
Article Details
References
Elaine Jaffe, Daniel A. Arber, Elias Campo Nancy, Lee Harris, Leticia Quintanilla-Fend. Hematopathology. Philadelphia, PA: Elsevier, [2017].
Ashton-Key, Margaret. Diagnostic Lymph Node Pathology Rosai-Dorfman disease. h t t p : / / w w w . p a t h o l o g y o u t l i n e s . c o m / topic/ breastmalignantrosaidorfman. html. PathologyOutlines.com website. Accessed May 18th, 2018.
Cai Yanan, Shi Zhangzhen, Bai Yuansong. Review of Rosai-Dorfman Disease: New Insights into the Pathogenesis of This Rare Disorder. Acta Haematol 2017;138: 14–23 DOI: 10.1159/000475588
Carpenter RJ III, Banks PM, Mc Donald TJ, Sanderson DR. Sinus histiocytosis with massive Lymphadenopathy (Rosai-Dorfman disease): Report of a case with respiratory tract involvement. Laryngoscope 1978;88:1963-9
Gómez Pinto DC, Vidigal Tde A, Castro Bd, Santos BH, Sousa NJ.. Rosai-Dorfman disease in the differential diagnosis of cervical lymphadenopathy. Rev Bras Otorrinolaringol 2008;74(4): 632-5
Lagasse E, Weissman. IL: Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood 1992; 79: 1907–1915
Liao HJ, Chiang CW. Toxoplasma IgG expressed in a patient with Rosai-Dorfman disease. Kaohsiung J Med Sci. 2010 Jul;26(7):373-6. doi: 10.1016/ S1607-551X(10)70061-9.
Liu M, Li X, Li Y (2017) Rosai-Dorfman disease with features of IgG4related disease in the breast: cases report and literature review. Asian Pac J Allergy Immunol 2018;36:51-57 DOI 10.12932/ AP0862.
Luppi M, Barozzi,P, Garber R (1998) Expression of human herpesvirus-6 antigens in benign and malignant lymphoproliferative disease. Am J Pathol 153: 815-823.
Mantilla J, Goldeberg-Stein S, Wang Yanhua. 2016. Extranodal Rosai Dorfman Disease. Clinicopathologic Series of 10 patients with radiologic correlation and review of literatute. American Journal of Paathology; 145:211-22. doi:10.1093/ajcp/aqv029.
Morgan NV, Morris MR, Cangul H, Gleeson D, Straatman-Iwanowska A, Davies N, Keenan S, Pasha S, Rahman F, Gentle D, Vreeswijk MP, Devilee P, Knowles MA, Ceylaner S, Trembath RC, Dalence C, Kismet E, Köseoğlu V, Rossbach HC, Gissen P, Tannahill D, Maher ER.. 2010. Mutations in SLC29A3, Encoding an Equilibrative Nucleoside Transporter ENT3, Cause a Familial Histiocytosis Syndrome (Faisalabad Histiocytosis) and Familial Rosai-Dorfman Disease. PLoS Genet 6(2): e1000833. doi:10.1371/journal. pgen.1000833
National Organization for Rare Disorders. Rosai- Dorfman Disease. https://rarediseases.org/rare- diseases/rosai-dorfman-disease/
Paulli M, Rosso R, Kindl S, Boveri E, Marocolo D, Chioda C, Agostini C, Magrini U, Facchetti F: Immunophenotypic characterization of the cell infiltrate in five case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman Disease). Hum Pathol 1992; 23: 647–654
Piris MA, Aguirregoicoa E, Montes-Moreno S, Celeiro-Muñoz C. Castleman Disease and Rosai-Dorfman Disease. Seminars in Diagnostic Pathology (2017), https://doi.org/10.1053/j.semdp.2017.11.014
Samir Dalia, MD, Elizabeth Sagatys, MD, Lubomir Sokol, MD, PhD, and Timothy Kubal, MD. Rosai– Dorfman Disease: Tumor Biology, Clinical Features, Pathology, and Treatment. Cancer Control. October 2014, Vol. 21, No. 4
Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathologicalentity. Arch Pathol. 1969; 87:63-70
Rosai J, Dorfman RF: Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder. Analysis of 34 cases. Cancer 1972; 30: 1174–1188
Tataroglu et al. Soft Tissue Rosai-Dorfman Disease with Unusual Histopathologic Features: A Case Report J Clin Exp Pathol 2017, 7:6
Hazarika P, Nayak DR, Balakrishnan R, Kundaje HG, Rao PL. RosaiDorfman disease of the subglottis. J Laryngol Otol 2000; 114:970-3
Gaitonde S. Multifocal, extranodal sinus histiocytosiswith massive lymphadenopathy: an overview. ArchPathol Lab Med 2007; 131:1117–21