Early use of non-invasive mechanical ventilation in premature neonates and its relative to the respiratory distress syndrome
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Abstract
The respiratory distress syndrome in the newborn is a condition very important in the
prematurity. The cause is the immature development of the respiratory tract and by deficiency of alveolar
surfactant. Objective: Determine if the early use of mechanical ventilation non-invasive in premature
newborn reduce respiratory distress, the use of invasive mechanical ventilation, use of surfactant and to
evaluate requirements day of oxygen and hospital stay. Method: historical cohort study. Data was collected
on history clinical of 123 patients, the variable were age, sex, gestational age, and hospital stay, use of
invasive mechanical ventilation, non-invasive ventilation, and use days of oxygen, use oxygen of discharge, use surfactant, pulmonary maturation, and diagnosis of bronchopulmonary dysplasia. Results: The use of mechanic ventilation non-invasive has decrease the relative risk of receiving surfactant to 0,28 (IC95 %
0,18 - 0,45) (p< 0,05), there was significant difference with respect to the use of oxygen at discharge with
RR of 1,41 (IC95 % 0,6 – 3,2) (p< 0,05)use of oxygen discharge with invasive ventilation versus a RR
of 0,89 (IC95 % 0,6 – 1,1) (p< 0,05 ventilation no invasive. Conclusions: The patients that received the
ventilation noninvasive have the relative risk of receiving low use surfactant, low dependence of oxygen at
discharge and development low broncopulmonary dysplasia.
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Cummings JJ, Polin RA, Committee on Fetus and Newborn AA of P. 2016. Noninvasive Respiratory Support. Pediatrics. 137(1):e20153758. doi:10.1542/peds.2015-3758.
Dargaville PA, Gerber A, Johansson S, De Paoli AG, Kamlin COF, Orsini F, Davis PG, Australian and New Zealand Neonatal Network. 2016. Incidence and Outcome of CPAP Failure in Preterm Infants. Pediatrics. 138(1):e20153985–e20153985. doi:10.1542/peds.2015-3985.
Hermansen CL, Mahajan A. 2015. Newborn Respiratory Distress. Am Fam Physician. 92(11):994–1002. doi:10.1053/j.sult.2015.01.005.
Isayama T, Chai-Adisaksopha C, McDonald SD. 2015. Noninvasive Ventilation With vs Without Early Surfactant to Prevent Chronic Lung Disease in Preterm Infants: A Systematic Review and Meta-analysis. JAMA Pediatr. 169(8):731–9. doi:10.1001/jamapediatrics.2015.0510.
Jobe A. 2014. Surfactant for Respiratory Distress Syndrome. Neoreviews. 15(6):e236–e245. doi:10.1542/neo.15-6-e236.
Kair LR, Leonard DT, Anderson JM, Med. 2012. Bronchopulmonary Dysplasia. Pediatr Rev. 33(6):255–264. doi:10.1542/pir.33-6-255.
Kennedy KA, Cotten CM, Watterberg KL, Carlo WA. 2016. Prevention and management of bronchopulmonary dysplasia: Lessons learned from the neonatal research network. Semin Perinatol. 40(6):348–355. doi:10.1053/j. semperi.2016.05.010.
Keszler M, Sant’Anna G. 2015. Mechanical Ventilation and Bronchopulmonary Dysplasia. Clin Perinatol. 42(4):781–96. doi:10.1016/j. clp.2015.08.006.
Laughon MM, Langer JC, Bose CL, Smith PB, Ambalavanan N, Kennedy KA, Stoll BJ, Buchter S, Laptook AR, Ehrenkranz RA, et al. 2016. Mechanical Ventilation and Bronchopulmonary Dysplasia. Clin Perinatol. 42(4):911–931. doi:10.1016/j.clp.2015.08.006.
Machado LC, Passini Júnior R, Rodrigues Machado Rosa I. 2014. Late prematurity: a systematic review. J Pediatr (Rio J). 90(3):221–231. doi:10.1016/j. jped.2013.08.012.
MurthyV,D’CostaW,ShahR,FoxGF,CampbellME, Milner AD, Greenough A. 2015. Prematurely born infants’response to resuscitation via an endotracheal tube or a face mask. Early Hum Dev. 91(3):235–8. doi:10.1016/j.earlhumdev.2015.02.004.
Polin RA, Carlo WA. 2014. Surfactant Replacement Therapy for Preterm and Term Neonates With Respiratory Distress. Pediatrics. 133(1):156–163. doi:10.1542/peds.2013-3443.
Reuter S, Moser C, Baack M. 2014. Respiratory distress in the newborn. Pediatr Rev. 35(10):417– 28; quiz 429. doi:10.1542/pir.35-10-417.
Roehr CC, Proquitté H, Hammer H, Wauer RR, Morley CJ, Schmalisch G. 2011. Positive effects of early continuous positive airway pressure on pulmonary function in extremely premature infants: results of a subgroup analysis of the COIN trial. Arch Dis Child Fetal Neonatal Ed. 96(5):F371-3. doi:10.1136/adc.2009.181008.
Sánchez, Ignacio; Prado F. 2007. Enfoque Clínico de las Enfermedades Respiratorias del Niño. Ediciones. Santiago.
Sandri F, Plavka R, Ancora G, Simeoni U, Stranak Z, Martinelli S, Mosca F, Nona J, Thomson M, Verder H, et al. 2010. Prophylactic or Early Selective Surfactant Combined With nCPAP in Very Preterm Infants. Pediatrics. 125(6):e1402– e1409. doi:10.1542/peds.2009-2131.
Stevens TP, Finer NN, Carlo WA, Szilagyi PG, Phelps DL, Walsh MC, Gantz MG, Laptook AR, Yoder BA, Faix RG, et al. 2014. Respiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT). J Pediatr. 165(2):240-249.e4. doi:10.1016/j.jpeds.2014.02.054.
Tang S, Zhao J, Shen J, Hu Z, Shi Y. 2013. Nasal intermittent positive pressure ventilation versus nasal continuous positive airway pressure in neonates: a systematic review and meta-analysis. Indian Pediatr. 50(4):371–6.
Weiner G. 2016. Textbook of Neonatal Resuscitation. 7ma ed. American Academy of Pediatrics and American Heart Association. Wright CJ, Polin RA. 2016. Noninvasive Support: Does It Really Decrease Bronchopulmonary Dysplasia? Clin Perinatol. 43(4):783-798. doi:10.1016/j.clp.2016.07.012.