Radiosensitizing effect of cyclohexanol succinate

Abstract

The purpose of this study was to assess the effect of the radiosensitizer cyclohexanol, a glucose antagonist drug. Fundamentally, the effects of lethality, depilatory effect and action on the fetuses in pregnant mice were considered.
 
 
It was found that the mean lethal dose of radiotherapy, in 30 days of observation (LD50/30), was 655 r., both for control animals and for those manually depilated before irradiation, doses less than 600r, were already capable of producing increased hair regeneration, erythema and skin ulcer. There were no significant differences between control animals and those treated with cyclohexanol.
 
 
When pregnant females were irradiated, it was found that while those given cyclohexanol gave birth to only 21 to 54% live pups, which died in the following days, females given no drugs gave birth to 90% live pups and there was a survival of 53%, which would demonstrate that cyclohexanol produces a radiosensitizing effect on young tissues