Uso del pez cebra (Danio rerio) como especie modelo para la investigación Biomédica
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El pez cebra (Danio rerio) es una especie de laboratorio usada mundialmente para el biodescubrimiento y la investigación biomédica experimental. Esta especie posee un genoma secuenciado y presenta facilidades para la manipulación genética por lo que es actualmente usada para modelar enfermedades humanas crónicas, infecciosas y cáncer en ensayos preclínicos. Al ser más pequeños y de alta fecundidad, el manejo de pez cebra es más económico en comparación con modelos de mamíferos. La facilidad de manipulación de embriones y larvas que se desarrollan en medios de cultivo permite el reemplazo, reducción y refinamiento en el uso de animales adultos para investigación. Estas características también facilitan su uso para ensayos masivos de cribado (screening) mutagénicos, toxicológicos o de biodescubrimiento. Esta revisión pretende resumir los puntos más importantes sobre el manejo y experimentación en el pez cebra.
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Galarza-Pichucho J, Arévalo Cuaical A, Ruano-Rivadeneira F, Zurita-Paredes D, Romero-Carvajal A. Uso del pez cebra (Danio rerio) como especie modelo para la investigación Biomédica . REMCB [Internet]. 5 de mayo de 2025 [citado 24 de junio de 2025];46(1). Disponible en: https://remcb-puce.edu.ec/remcb/article/view/1039
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Eisen, J.S., 2020. History of zebrafish research. The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications 3–14. https://doi.org/10.1016/B978-0-12-812431-4.00001-4
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