Análisis del potencial genotóxico y carcinógeno asociado a los cigarrillos electrónicos

Contenido principal del artículo

Isaac Armendáriz - Castillo
Santiago Guerrero
Antonella Vera-Guapi
Tiffany Cevallos-Vilatuña
Jennyfer M. Garcí­a-Cárdenas
Patricia Guevara-Ramí­rez
Andrés López-Cortés
Andy Pérez-Villa
Verónica Yumiceba
Ana K. Zambrano
Paola E. Leone
Cesar Paz y Miño

Resumen

Diferentes estudios que comparan riesgos a la salud asociados a los usos de cigarrillos electrónicos y convencionales, se enfocan principalmente en compuesto quí­micos en común entre ambos sistemas. Por lo tanto, realizamos una revisión de compuestos quí­micos exclusivos de cigarrillos electrónicos. Los criterios de selección incluyeron artí­culos que reporten composición quí­mica y riesgos asociados a la salud, sin conflictos de interés. Todos los compuestos quí­micos fueron clasificados según el código del "Chemical Abstracts Service" para sustancias quí­micas. Un total de 57 compuestos fueron identificados en cigarrillos electrónicos. Para analizar los efectos carcinogénicos, un set de genes, previamente reportados como desregulados en el epitelio oral de usuarios de cigarrillos electrónicos, fueron genómicamente analizados en 32 estudios del "PanCancer Atlas". Los riesgos a la salud más importantes incluyen: irritación de tracto respiratorio, ojos y piel con un 50% de incidencia. Los tipos de cáncer con mayor riesgo identificados fueron: ovario, útero, vejiga, pulmón, esófago y estómago. A pesar de ser considerados como menos dañinos que los cigarrillos convencionales, el uso de cigarrillos electrónicos no es recomendado para ningún usuario, debido a falta de evidencia experimental.

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Armendáriz - Castillo I, Guerrero S, Vera-Guapi A, Cevallos-Vilatuña T, Garcí­a-CárdenasJM, Guevara-Ramí­rezP, López-Cortés A, Pérez-Villa A, Yumiceba V, Zambrano AK, Leone PE, Paz y Miño C. Análisis del potencial genotóxico y carcinógeno asociado a los cigarrillos electrónicos. REMCB [Internet]. 25 de mayo de 2020 [citado 24 de junio de 2024];41(1). Disponible en: https://remcb-puce.edu.ec/remcb/article/view/835
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