El losartán disminuye la expresión del receptor para compuestos de glicosilación avanzada en el tejido cardiaco de ratas diabéticas

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Nelson Muñoz
Jesus Mosquera
Adriana Pedreañez Santana

Resumen

El receptor para productos finales de glicación avanzada (RAGE) puede interactuar con diversos ligandos e inducir procesos inflamatorios. El objetivo de esta investigación fue determinar el efecto del enalapril y losartán sobre la expresión de RAGE en el tejido cardíaco en un modelo experimental de diabetes. Se utilizaron ratas Sprague-Dawley machos, con un peso de 150 - 200 g. La diabetes se indujo en 30 ratas mediante la administración intravenosa de una sola dosis de 55 mg/Kg de peso corporal de estreptozotocina (ETZ). Se estudiaron los siguientes grupos: ratas control, diabéticas, diabéticas tratadas con losartán y diabéticas tratadas con enalapril. La expresión de RAGE en miocardio se determinó por inmunofluorescencia indirecta. Se observó un aumento significativo en la expresión de RAGE en los animales diabéticos versus los controles (p<0.01), hubo una disminución en la expresión de RAGE miocárdico, sólo en los animales tratados con losartán versus los diabéticos sin tratamiento (p<0.05). En conclusión, en el modelo experimental de diabetes inducida por ETZ, existe un incremento en la expresión miocárdica de RAGE, la cual puede revertirse mediante el tratamiento con losartán lo cual indica la participación del sistema renina angiotensina en los mecanismos relacionados con el daño cardiaco durante la diabetes.

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Muñoz N, Mosquera J, Pedreañez Santana A. El losartán disminuye la expresión del receptor para compuestos de glicosilación avanzada en el tejido cardiaco de ratas diabéticas. REMCB [Internet]. 23 de abril de 2021 [citado 21 de julio de 2024];42(1). Disponible en: https://remcb-puce.edu.ec/remcb/article/view/883
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