Análisis retrospectivo de biomarcadores asociados con la mortalidad en pacientes con COVID-19
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El virus de SARS-CoV-2 causa cuadros respiratorios leve hasta neumonías graves. Los pacientes críticos pueden presentar varias complicaciones y requerir ventilación mecánica invasiva lo que incrementa su mortalidad. Identificar los factores de riesgo de muerte, modificables, nos permite tomar decisiones terapéuticas reales. El objetivo del estudio retrospectivo fue determinar si la elevación del dímero D, al ingreso a Unidad de Cuidados Intensivos (UCI), es un factor de riesgo de mortalidad para los pacientes críticos con neumonía por SARS-CoV-2. El estudio se realizó en una unidad de cuidados intensivos de segundo nivel de la ciudad de Quito-Ecuador. Se reclutó a todos los pacientes mayores de 18 años, con diagnóstico de neumonía por SARS-CoV-2 que ingresaron a la unidad y con resultado inicial de dímero D. Se recolectaron variables demográficas, clínica, de laboratorio, de estudios de imagen, desenlaces y tratamiento. Los niveles de creatinina sérica fueron significativamente mayores en los pacientes fallecidos y con edad avanzada. Este estudio sugiere una posible relación entre injuria renal aguda y un incremento de la mortalidad de los pacientes. Además, el estudio sugiere evaluar el dímero D en una cohorte más grande para tener una potencia estadística que respalde con la información reportada por otros autores.
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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
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